At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia.

doi:10.1016/j.biopsych.2011.01.031

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Article

At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia.

Biological psychiatry - 1 Jul 2011

Hansen Thomas, Ingason Andrés, Djurovic Srdjan, Melle Ingrid, Fenger Mogens, Gustafsson Omar, Jakobsen Klaus D, Rasmussen Henrik B, Tosato Sarah, Rietschel Marcella, Frank Josef, Owen Mike, Bonetto Chiara, Suvisaari Jaana, Thygesen Johan Hilge, Pétursson Hannes, Lönnqvist Jouko, Sigurdsson Engilbert, Giegling Ina, Craddock Nick, O'Donovan Michael C, Ruggeri Mirella, Cichon Sven, Ophoff Roel A, Pietiläinen Olli, Peltonen Leena, Nöthen Markus M, Rujescu Dan, St Clair David, Collier David A, Andreassen Ole A, Werge Thomas

Abstract excerpt

BACKGROUND: Schizophrenia is associated with increased risk of type II diabetes and metabolic disorders. However, it is unclear whether this comorbidity reflects shared genetic risk factors, at-risk lifestyle, or side effects of antipsychotic medication. METHODS: Eleven known risk variants of type II diabetes were genotyped in patients with schizophrenia in a sample of 410 Danish patients, each matched with two...

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PMID: 21414605
DOI: 10.1016/j.biopsych.2011.01.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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