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Article

Renaturation of denatured lambda repressor requires heat shock proteins.

Cell - 15 Jun 1990

Gaitanaris G A, Papavassiliou A G, Rubock P, Silverstein S J, Gottesman M E

Abstract excerpt

The temperature-sensitive bacteriophage lambda cI857 repressor protein rapidly renatures after thermal inactivation. E. coli mutants in the heat shock protein genes dnaK, dnaJ, and grpE do not efficiently reactivate heat-denatured repressor. Our results suggest that protein refolding is promoted by heat shock proteins and that such a process is the basis of the homeostatic role played by these proteins in the...

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PMID: 2140957
DOI: 10.1016/0092-8674(90)90066-n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Renaturation of denatured lambda repressor requires heat shock proteins.PMID 2140957Read ↗

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Successive action of Escherichia coli chaperones in vivo.Semantic proximity Read ↗

DnaK heat shock protein of Escherichia coli maintains the negative supercoiling of DNA against thermal stress.Semantic proximity Read ↗

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