Renaturation of denatured lambda repressor requires heat shock proteins.

doi:10.1016/0092-8674(90)90066-n

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Article

Renaturation of denatured lambda repressor requires heat shock proteins.

Cell - 15 Jun 1990

Gaitanaris G A, Papavassiliou A G, Rubock P, Silverstein S J, Gottesman M E

Abstract excerpt

The temperature-sensitive bacteriophage lambda cI857 repressor protein rapidly renatures after thermal inactivation. E. coli mutants in the heat shock protein genes dnaK, dnaJ, and grpE do not efficiently reactivate heat-denatured repressor. Our results suggest that protein refolding is promoted...

Topics

Bacteriophage lambda
DNA Probes
DNA-Binding Proteins
Escherichia coli
Galactokinase
Genotype
Heat-Shock Proteins
Kinetics
Mutation
Protein Binding
Protein Conformation
Protein Denaturation
Repressor Proteins
Transcription Factors
Viral Proteins
Viral Regulatory and Accessory Proteins

Source

Open in PubMed

Identifiers

PMID: 2140957
DOI: 10.1016/0092-8674(90)90066-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2140957-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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