Article
Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam.
PLoS neglected tropical diseases - 1 Mar 2011
Fox Annette, Le Nguyen Minh Hoa, Simmons Cameron P, Wolbers Marcel, Wertheim Heiman F L, Pham Thi Khuong, Tran Thi Hai Ninh, Trinh Thi Minh Lien, Nguyen Thi Lien, Nguyen Vu Trung, Nguyen Duc Hien, Farrar Jeremy, Horby Peter, Taylor Walter R, Nguyen Van Kinh
Abstract excerpt
BACKGROUND: The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. METHODS AND FINDINGS: 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm...
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