Article
Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.
Dermatology (Basel, Switzerland) - 1 Jan 2015
Burger Bettina, Spörri Iris, Stegmann Danielle A, De Mesmaker Julie, Schaub Stefan, Itin Peter H, Steiger Jürg, Arnold Andreas W
Abstract excerpt
BACKGROUND: Renal transplant recipients (RTRs) have an increased risk of developing nonmelanoma skin cancer, mainly cutaneous squamous cell carcinoma (cSCC). Two genes (TMC6/EVER1 and TMC8/EVER2), mutated in epidermodysplasia verruciformis (EV) patients with an increased risk of cSCC development, contain numerous single-nucleotide polymorphisms (SNPs). AIM: To evaluate the effect of SNPs in both TMC/EVER genes on...
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