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Article

Quantitative epigenetics through epigenomic perturbation of isogenic lines.

Genetics - 1 May 2011

Johannes Frank, Colomé-Tatché Maria

Abstract excerpt

Interindividual differences in chromatin states at a locus (epialleles) can result in gene expression changes that are sometimes transmitted across generations. In this way, they can contribute to heritable phenotypic variation in natural and experimental populations independent of DNA sequence. Recent molecular evidence shows that epialleles often display high levels of transgenerational instability. This...

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Identifiers

PMID: 21385727
DOI: 10.1534/genetics.111.127118
PMCID: PMC3120148

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