Article
Assessing the impact of transgenerational epigenetic variation on complex traits.
PLoS genetics - 1 Jun 2009
Johannes Frank, Porcher Emmanuelle, Teixeira Felipe K, Saliba-Colombani Vera, Simon Matthieu, Agier Nicolas, Bulski Agnès, Albuisson Juliette, Heredia Fabiana, Audigier Pascal, Bouchez David, Dillmann Christine, Guerche Philippe, Hospital Frédéric, Colot Vincent
Abstract excerpt
Loss or gain of DNA methylation can affect gene expression and is sometimes transmitted across generations. Such epigenetic alterations are thus a possible source of heritable phenotypic variation in the absence of DNA sequence change. However, attempts to assess the prevalence of stable epigenetic variation in natural and experimental populations and to quantify its impact on complex traits have been hampered by...
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