Article
Genetic rearrangements can modify chromatin features at epialleles.
PLoS genetics - 1 Oct 2011
Foerster Andrea M, Dinh Huy Q, Sedman Laura, Wohlrab Bonnie, Mittelsten Scheid Ortrun
Abstract excerpt
Analogous to genetically distinct alleles, epialleles represent heritable states of different gene expression from sequence-identical genes. Alleles and epialleles both contribute to phenotypic heterogeneity. While alleles originate from mutation and recombination, the source of epialleles is less well understood. We analyze active and inactive epialleles that were found at a transgenic insert with a selectable...
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