Article
What hope for the future? GNAQ and uveal melanoma.
The British journal of ophthalmology - 1 May 2011
Sisley Karen, Doherty Rachel, Cross Neil A
Abstract excerpt
Uveal melanomas (UM) are aggressive ocular tumours that spread to the liver. They are characterised by alterations of chromosome 3 and 8, which are highly predictive of a poor prognosis. Unfortunately, being able to identify those patients with aggressive disease has not, as yet, translated into improved survival. Recently, mutations of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ, or G-alpha-q),...
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