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Article

Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.

PloS one - 18 Feb 2011

McFarland Adelle P, Savan Ram, Wagage Sagie, Addison Augustina, Ramakrishnan Karthika, Karwan Megan, Duong Tri, Young Howard A

Abstract excerpt

BACKGROUND: There have been conflicting reports of the role of Type I interferons (IFN) in inflammatory bowel disease (IBD). Clinical trials have shown potent efficacy of systemic interferon-beta (IFN-β) in inducing remission of ulcerative colitis. Likewise, IFNAR1(-/-) mice display an increased sensitivity to dextran sulfate sodium (DSS)-induced colitis, suggesting Type I IFN play a protective role during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21365015
DOI: 10.1371/journal.pone.0016967
PMCID: PMC3041828

Genes

IFNAR1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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