Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.

doi:10.1002/jmv.22038

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Article

Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.

Journal of medical virology - 1 May 2011

Sakamoto Naoya, Nakagawa Mina, Tanaka Yasuhito, Sekine-Osajima Yuko, Ueyama Mayumi, Kurosaki Masayuki, Nishida Nao, Tamori Akihiro, Yuki Nishimura-Sakurai, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Hige Shuhei, Itoh Yoshito, Tanaka Eiji, Hiasa Yoichi, Izumi Namiki, Tokunaga Katsushi, Mizokami Masashi, Watanabe Mamoru

Abstract excerpt

Genetic polymorphisms of the interleukin 28B (IL28B) locus are associated closely with outcomes of pegylated-interferon (PEG-IFN) plus ribavirin (RBV) combination therapy. The aim of this study was to investigate the relationship between IL28B polymorphism and responses to therapy in patients infected with genotype 2. One hundred twenty-nine chronic hepatitis C patients infected with genotype 2, 77 patients with...

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PMID: 21360545
DOI: 10.1002/jmv.22038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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