Article
Understanding the polymorphic behaviour of a mutant of the α-spectrin SH3 domain by means of two 1.1 Å resolution structures.
Acta crystallographica. Section D, Biological crystallography - 1 Mar 2011
Cámara-Artigas Ana, Gavira Jose Antonio, Casares Salvador, Garcia-Ruiz Juan Manuel, Conejero-Lara Francisco, Allen James P, Martinez Jose C
Abstract excerpt
SH3 domains are small protein modules that mediate the assembly of specific protein complexes, typically via binding to proline-rich sequences in their respective binding partners. Most of the α-spectrin SH3-domain (Spc-SH3) structures determined to date using X-ray diffraction have been solved from crystals belonging to the orthorhombic space group P2(1)2(1)2(1) with a needle-like morphology. All of these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.