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Article

Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications.

International journal of antimicrobial agents - 1 Apr 2011

Lee Hao-Yuan, Chen Chyi-Liang, Wang Shi-Bo, Su Lin-Hui, Chen Shu-Hung, Liu Shu-Ying, Wu Tsu-Lan, Lin Tzou-Yien, Chiu Cheng-Hsun

Abstract excerpt

Acinetobacter baumannii has emerged as a major pathogen causing nosocomial infections, particularly in critical patients admitted to the Intensive Care Unit. Increasing resistance to carbapenems in A. baumannii has been observed worldwide. Here we report the clinical impact and mechanism of imipenem heteroresistance (imipenem minimum inhibitory concentration of 6-32 μg/mL with the presence of resistant cells...

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PMID: 21353490
DOI: 10.1016/j.ijantimicag.2010.12.015

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