Loss of Wnt-5α is associated with an invasive phenotype of extramammary Paget's disease.

Abstract excerpt

BACKGROUND: The Wnt (wingless-type MMTV integration site) gene family encodes secretory signaling molecules that play a diverse biological role in the regulation of normal and pathological processes, including cell growth, differentiation and oncogenesis. However, the role of Wnt genes in the development of extramammary Paget's disease remains unknown. OBJECTIVE: To investigate the expression of Wnt-1, Wnt-5α and...

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