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Article

The role of HER-2/neu oncogene and vimentin filaments in the production of the Paget's phenotype.

The breast journal - 1 Jan 2000

Hanna Wedad, Alowami Salem, Malik Abha

Abstract excerpt

The histogenesis as well as the biological and molecular differences in mammary Paget's disease (MPD) and extramammary Paget's disease (EPD) are not well understood. HER-2/neu oncogene overexpression is associated with poor prognosis in breast cancer patients. It is also believed that the spread of Paget's cells through the epidermis is induced by a motility factor that acts via the HER-2/neu receptor. However,...

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Identifiers

PMID: 14616943
DOI: 10.1046/j.1524-4741.2003.09610.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of HER-2/neu oncogene and vimentin filaments in the production of the Paget's phenotype.PMID 14616943Read ↗

Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells.Semantic proximity Read ↗

Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas.Semantic proximity Read ↗

HER-2 Gene Amplification in Paget Disease of the Nipple and Extramammary Site: A Chromogenic In Situ Hybridization StudySemantic proximity Read ↗

Toker cells revisited.Semantic proximity Read ↗

Intraepidermal cells of Paget's carcinoma of the breast can be genetically different from those of the underlying carcinoma.Semantic proximity Read ↗

Loss of Wnt-5α is associated with an invasive phenotype of extramammary Paget's disease.Semantic proximity Read ↗

Single-cell RNA sequencing provides insights into the potential cellular origins and microenvironment of Extramammary Paget's disease.Semantic proximity Read ↗

Extramammary Paget's disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies.Semantic proximity Read ↗

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