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Article

IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells.

Journal of cellular physiology - 1 Dec 2011

Wu Chi-Ming, Li Te-Mao, Hsu Sheng-Feng, Su Yi-Chang, Kao Shung-Te, Fong Yi-Chin, Tang Chih-Hsin

Abstract excerpt

Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Integrins are the major adhesive molecules in mammalian cells and have been associated with metastasis of cancer cells. Insulin-like growth factor-I (IGF)-I plays an important role in regulating cell growth, proliferation,...

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Source

Identifiers

PMID: 21344385
DOI: 10.1002/jcp.22688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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