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Article

CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis

22 Feb 2011

Abstract excerpt

Spermatogenesis is a highly programmed process that requires the degradation of the extracellular matrix and the remodeling of tight junctions (TJ) to facilitate differentiating germ cell migration. Matrix metalloproteinases (MMPs) are essential in regulating Sertoli cell TJ in the testis. CD147 is known to stimulate the production of MMPs in tumor metastasis and its knockout mice are infertile. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21343160
DOI: 10.1093/molehr/gar013

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