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Article

Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues.

Chemistry & biology - 25 Feb 2011

Rosado Abel, Hicks Glenn R, Norambuena Lorena, Rogachev Ilana, Meir Sagit, Pourcel Lucille, Zouhar Jan, Brown Michelle Q, Boirsdore Marietta P, Puckrin Rachel S, Cutler Sean R, Rojo Enrique, Aharoni Asaph, Raikhel Natasha V

Abstract excerpt

Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers. To better understand its mode of action, we designed a Sortin1-hypersensitive screen and identified several Sortin1-hypersensitive and flavonoid-defective mutants. Mechanistically, Sortin1 mimics the effect of the glutathione inhibitor buthionine sulfoximine and alters the...

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PMID: 21338917
DOI: 10.1016/j.chembiol.2010.11.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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