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Article

Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

Aquatic toxicology (Amsterdam, Netherlands) - 1 Nov 2017

Holland Erika B, Goldstone Jared V, Pessah Isaac N, Whitehead Andrew, Reid Noah M, Karchner Sibel I, Hahn Mark E, Nacci Diane E, Clark Bryan W, Stegeman John J

Abstract excerpt

Non-dioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine receptors (RyR), microsomal Ca2+ channels of broad significance. Teleost fish may be important models for NDL PCB neurotoxicity, and we used sequencing databases to characterize teleost RyR and FK506 binding protein 12 or 12.6kDa (genes FKBP1A; FKBP1B), which promote NDL PCB-triggered Ca2+ dysregulation. Particular focus was placed on...

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Identifiers

PMID: 28942070
DOI: 10.1016/j.aquatox.2017.09.002
PMCID: PMC5662517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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