Article
Interactive role of trauma cytokines and erythropoietin and their therapeutic potential for acute and chronic wounds.
Rejuvenation research - 1 Feb 2011
Bader Augustinus, Lorenz Katrin, Richter Anja, Scheffler Katja, Kern Larissa, Ebert Sabine, Giri Shibashish, Behrens Maria, Dornseifer Ulf, Macchiarini Paolo, Machens Hans-Günther
Abstract excerpt
If controllable, stem cell activation following injury has the therapeutic potential for supporting regeneration in acute or chronic wounds. Human dermally-derived stem cells (FmSCs) were exposed to the cytokines interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in the presence of erythropoietin (EPO). Cells were cultured under ischemic conditions and phenotypically characterized using flow...
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