Article
Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese.
Genes and immunity - 1 Apr 2011
Zhang Y, Yang W, Mok C C, Chan T M, Wong R W S, Mok M Y, Lee K W, Wong S N, Leung A M H, Lee T L, Ho M H K, Lee P P W, Wong W H S, Yang J, Zhang J, Wong C-M, Ng I O L, Garcia-Barceló M-M, Cherny S S, Tam P K-H, Sham P C, Lau C S, Lau Y L
Abstract excerpt
UHRF1BP1 encodes a highly conserved protein with unknown function. Previously, a coding variant in this gene was found to be associated with systemic lupus erythematosus (SLE) in populations of European ancestry (rs11755393, R454Q, P=2.22 x 10⁻⁸, odds ratio=1.17). In this study, by a combination of genome-wide study and replication involving a total of 1230 patients and 3144 controls, we confirmed the association...
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