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Article

Keratin 14-null cells as a model to test the efficacy of gene therapy approaches in epithelial cells.

The Journal of investigative dermatology - 1 Jul 2011

D'Alessandro Mariella, Coats Stephanie E, Jonkman Marcel F, Jonkmann Marcel F, Leigh Irene M, Lane E Birgitte

Abstract excerpt

Skin fragility disorders caused by keratin mutations are incurable, and a better understanding of their etiology is needed to find new ways to improve and treat these conditions. The best-studied skin fragility disorder is epidermolysis bullosa simplex (EBS), an autosomal dominant condition caused by mutations in keratin 5 (K5) or K14. To analyze disease mechanisms and develop gene therapy strategies, we have...

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Identifiers

PMID: 21326298
DOI: 10.1038/jid.2011.19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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