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Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation

15 Feb 2011

Abstract excerpt

Spermatogenesis is absolutely dependent on FSH and androgens; suppression of these hormones inhibits germ cell development and thus sperm production. The final release of spermatids by the Sertoli cell, a process known as spermiation, is particularly sensitive to hormone suppression. To define the molecular mechanisms that mediate FSH and androgen effects in the Sertoli cell, we investigated the expression and...

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PMID: 21325043
DOI: 10.1210/en.2010-1341

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