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Article

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

15 Feb 2011

Abstract excerpt

Despite available therapies, myocardial infarction (MI) remains a leading cause of death worldwide. Better understanding of the molecular and cellular mechanisms that regulate cardiac repair should help to improve the clinical outcome of MI patients. Using the reporter mouse line TOPGAL, we show that canonical (β-catenin-dependent) Wnt signaling is induced 4 days after experimental MI in subepicardial endothelial...

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PMID: 21324930
DOI: 10.1242/dmm.006510

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