Article
Distribution of EGFR mutations commonly observed in primary lung adenocarcinomas in Pakistan as predictors for targeted therapy.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Ahmed Zeeshan Ansar, Moatter Tariq, Siddiqui Areeba, Pervez Shahid
Abstract excerpt
BACKGROUND: Acquired genetic alterations and presence of sensitizing mutations in the tyrosine kinase domain of EGFR and other signaling molecules have been found in different subsets of primary lung adenocarcinoma. The commonest EGFR mutations are small in frame deletions of exon 19 and a point mutation (L858R) in exon 21, having a combined occurrence of around 90%. The objective of this study was to determine...
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