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Article

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.

The Journal of experimental medicine - 19 Dec 2011

Purtha Whitney E, Tedder Thomas F, Johnson Syd, Bhattacharya Deepta, Diamond Michael S

Abstract excerpt

Memory B cells (MBCs) and long-lived plasma cells (LLPCs) persist after clearance of infection, yet the specific and nonredundant role MBCs play in subsequent protection is unclear. After resolution of West Nile virus infection in mice, we demonstrate that LLPCs were specific for a single dominant neutralizing epitope, such that immune serum poorly inhibited a variant virus that encoded a mutation at this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22162833
DOI: 10.1084/jem.20110740
PMCID: PMC3244041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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