Inhibition of TGFBIp Expression by Lithium: Implications for<i>TGFBI</i>-Linked Corneal Dystrophy Therapy

Abstract excerpt

PURPOSE. The purpose of this study was to investigate the effects and molecular mechanisms of lithium on inhibition of TGFBIp expression as a potential therapy for TGFBI-linked corneal dystrophy. METHODS. Primary culture corneal fibroblasts were isolated from the corneas of healthy subjects and patients with granular corneal dystrophy type 2 (GCD2) with a homozygous mutation in TGFBI R124H. Levels of TGFBIp and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connective Tissue Growth Factor Research
• Share to Corneal Surgery and Treatments
• Share to TGF-β signaling in diseases