Article
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study.
PLoS genetics - 3 Feb 2011
Nica Alexandra C, Parts Leopold, Glass Daniel, Nisbet James, Barrett Amy, Sekowska Magdalena, Travers Mary, Potter Simon, Grundberg Elin, Small Kerrin, Hedman Asa K, Bataille Veronique, Tzenova Bell Jordana, Surdulescu Gabriela, Dimas Antigone S, Ingle Catherine, Nestle Frank O, di Meglio Paola, Min Josine L, Wilk Alicja, Hammond Christopher J, Hassanali Neelam, Yang Tsun-Po, Montgomery Stephen B, O'Rahilly Steve, Lindgren Cecilia M, Zondervan Krina T, Soranzo Nicole, Barroso Inês, Durbin Richard, Ahmadi Kourosh, Deloukas Panos, McCarthy Mark I, Dermitzakis Emmanouil T, Spector Timothy D
Abstract excerpt
While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore in depth the role of cis-regulatory variation in three human tissues: lymphoblastoid cell lines (LCL), skin, and fat. The samples (156 LCL, 160 skin, 166 fat) were derived simultaneously from a subset of well-phenotyped healthy...
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