Article
Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour.
European archives of psychiatry and clinical neuroscience - 1 Dec 2011
Pinto Crystal, Souza Renan P, Lioult Diane, Semeralul Mawahib, Kennedy James L, Warsh Jerry J, Wong Albert H, Luca Vincenzo De
Abstract excerpt
Suicide and suicidal behaviour are a major health concern worldwide particularly in patients with mood disorders. Family, adoption and twin studies show that genetics influences suicidal behaviour. The serotonin transporter (5HTT) plays an important role in the pathophysiology of mood disorders and may also be involved in suicidal behaviour since 5HTT binding is decreased in the brain of suicide completers....
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