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Article

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

Trends in cell biology - 1 May 2013

Kirchner Henriette, Osler Megan E, Krook Anna, Zierath Juleen R

Abstract excerpt

Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone modifications are thought to play an important role in the development of and predisposition to metabolic diseases. This review highlights the key functions of DNA methylation and histone modifications and elucidates the underlying mechanisms...

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Identifiers

PMID: 23277089
DOI: 10.1016/j.tcb.2012.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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