Article
Mutation detection and accurate diagnosis of extensively drug-resistant tuberculosis: report from a tertiary care center in India.
Journal of clinical microbiology - 1 Apr 2011
Ajbani Kanchan, Rodrigues Camilla, Shenai Shubhada, Mehta Ajita
Abstract excerpt
We screened and spoligotyped 150 consecutive phenotypically confirmed extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) isolates (January 2008 to March 2009) for rifampin, isoniazid, fluoroquinolone, and aminoglycoside resistance targeting rpoB, inhA, katG, gyrA, gyrB, and rrs. Mutations predominant among XDR-TB were S315T (katG) (100% of isolates), S531L (rpoB) (97% of isolates), D94G (gyrA) (53% of...
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