Article
A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera's neonatal ataxia.
Journal of veterinary internal medicine - 1 Jan 2000
Zeng R, Farias F H G, Johnson G S, McKay S D, Schnabel R D, Decker J E, Taylor J F, Mann C S, Katz M L, Johnson G C, Coates J R, O'Brien D P
Abstract excerpt
BACKGROUND: Bandera's neonatal ataxia (BNAt) is an autosomal recessive cerebellar ataxia that affects members of the Coton de Tulear dog breed. OBJECTIVE: To identify the mutation that causes BNAt. ANIMALS: The study involved DNA from 112 Cotons de Tulear (including 15 puppies with signs of BNAt) and 87 DNA samples from dogs of 12 other breeds. METHODS: The BNAt locus was mapped with a genome-wide association...
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