Article
Evolutionary features and intracellular behavior of the PRTB protein.
Biochemical genetics - 1 Aug 2011
Matsunami Miki, Yoshioka Takashi, Minoura Tokiko, Okano Yukio, Muto Yoshinori
Abstract excerpt
Human PRTB encodes a proline-rich protein of 168 amino acids (PRTB). We analyzed the evolutionary patterns of PRTB from various vertebrate species. Maximum likelihood analyses indicated that while mammalian PRTB has been very well conserved and underwent a significantly slower rate of evolution, only the branch leading to fish PRTB has undergone adaptive evolution. We generated several mutant PRTBs fused to the...
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