Article
Polymorphism of the ovine FOXP3 gene (FOXP3).
Veterinary immunology and immunopathology - 15 Apr 2011
Yang Guo, Zhou Huitong, Hickford Jon G H
Abstract excerpt
FOXP3 is a transcription factor predominantly expressed in CD4(+) CD25(+) thymocytes and CD4(+) CD25(+) peripheral T cells. It has been reported that variation in the FOXP3 gene (FOXP3) could cause impaired immune regulation. Using PCR-SSCP, variation in exon 4, exon 9-10 and exon 13-14 of ovine FOXP3, covering three functional domains (a proline rich domain, a leucine zipper-like motif and the forkhead domain,...
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