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Article

Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes

27 Jan 2011

Abstract excerpt

OBJECTIVE: Genetic defects in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteodysplastic primordial dwarfism that is sometimes reported to be associated with diabetes. We thus set out to determine the prevalence of diabetes and insulin resistance among patients with PCNT defects and examined the effects of pericentrin depletion on insulin action using 3T3-L1 adipocytes...

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PMID: 21270239
DOI: 10.2337/db10-1334

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