Article
The P-loop--a common motif in ATP- and GTP-binding proteins.
Trends in biochemical sciences - 1 Nov 1990
Saraste M, Sibbald P R, Wittinghofer A
Abstract excerpt
Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of...
Topics
- Adenosine Triphosphate
- Amino Acid Sequence
- Animals
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Proteins
- Sequence Homology, Nucleic Acid