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Article

Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1.

The journal of physical chemistry. B - 17 Feb 2011

Yan Chunli, Kaoud Tamer, Lee Sunbae, Dalby Kevin N, Ren Pengyu

Abstract excerpt

The up-regulation of JNK activity is associated with a number of disease states. The JNK-JIP1 interaction represents an attractive target for the inhibition of JNK-mediated signaling. In this study, molecular dynamics simulations have been performed on the apo-JNK1 and the JNK1•L-pepJIP1 and JNK1•D-pepJIP1 complexes to investigate the interaction between the JIP1 peptides and JNK1. Dynamic domain studies based on...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21261310
DOI: 10.1021/jp1073522
PMCID: PMC3042137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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