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Article

A missense mutation in the 20S proteasome β2 subunit of Great Danes having harlequin coat patterning.

Genomics - 1 Apr 2011

Clark Leigh Anne, Tsai Kate L, Starr Alison N, Nowend Keri L, Murphy Keith E

Abstract excerpt

Harlequin is a pigmentary trait of the domestic dog that is controlled by two autosomal loci: the melanosomal gene, SILV, and a modifier gene, harlequin (H), previously localized to chromosome 9. Heterozygosity for a retrotransposon insertion in SILV and a mutation in H causes a pattern of black patches on a white background. Homozygosity for H is embryonic lethal. Fine mapping of the harlequin locus revealed a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21256207
DOI: 10.1016/j.ygeno.2011.01.003

Genes

PSMB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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