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The PMEL gene and merle (dapple) in the dachshund: cryptic, hidden, and mosaic variants demonstrate the need for genetic testing prior to breeding.

Human genetics - 1 Nov 2021

Ballif Blake C, Emerson Lisa J, Ramirez Christina J, Carl Casey R, Sundin Kyle, Flores-Smith Helen, Shaffer Lisa G

Abstract excerpt

One of the most unique coat color patterns in the domestic dog is merle (also known as dapple in the dachshund breed), characterized by patches of normal pigmentation surrounded by diluted eumelanin pigment. In dogs, this striking variegated pattern is caused by an insertion of a SINE element into the PMEL gene. Differences in the length of the SINE insertion [due to a variable-length poly(A)-tail] has been...

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PMID: 34370083
DOI: 10.1007/s00439-021-02330-y

Genes

PMEL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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