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Novel Brown Coat Color (Cocoa) in French Bulldogs Results from a Nonsense Variant in HPS3.

Genes - 9 Jun 2020

Kiener Sarah, Kehl Alexandra, Loechel Robert, Langbein-Detsch Ines, Müller Elisabeth, Bannasch Danika, Jagannathan Vidhya, Leeb Tosso

Abstract excerpt

Brown or chocolate coat color in many mammalian species is frequently due to variants at the B locus or TYRP1 gene. In dogs, five different TYRP1 loss-of-function alleles have been described, which explain the vast majority of dogs with brown coat color. Recently, breeders and genetic testing laboratories identified brown French Bulldogs that did not carry any of the known mutant TYRP1 alleles. We sequenced the...

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Identifiers

PMID: 32526956
DOI: 10.3390/genes11060636
PMCID: PMC7349258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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