Article
Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS).
Progress in neuro-psychopharmacology & biological psychiatry - 30 Mar 2011
Hotta Yuri, Ohnuma Tohru, Hanzawa Ryo, Shibata Nobuto, Maeshima Hitoshi, Baba Hajime, Hatano Tokiko, Takebayashi Yuto, Kitazawa Maiko, Higa Motoyuki, Suzuki Toshihito, Arai Heii
Abstract excerpt
Treating the 20-30% of patients with schizophrenia whose symptoms are resistant to antipsychotic treatment, a condition known as treatment-resistant schizophrenia (TRS), can be problematic. Recently, an association between Disrupted-in-Schizophrenia-1 (DISC1), a candidate susceptibility gene for schizophrenia, and TRS was reported. Associations between three missense SNPs, rs3738401 (Q264R), rs6675281 (L607F),...
Read the complete abstract on PubMed