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Article

Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.

Nature reviews. Cancer - 1 Feb 2011

Huff Vicki

Abstract excerpt

Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an...

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Source

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Identifiers

PMID: 21248786
DOI: 10.1038/nrc3002
PMCID: PMC4332715

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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