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Side effects of retroviral gene transfer into hematopoietic stem cells

27 Feb 2003

Abstract excerpt

Recent conceptual and technical improvements have resulted in clinically meaningful levels of gene transfer into repopulating hematopoietic stem cells. At the same time, evidence is accumulating that gene therapy may induce several kinds of unexpected side effects, based on preclinical and clinical data. To assess the therapeutic potential of genetic interventions in hematopoietic cells, it will be important to...

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PMID: 12511419
DOI: 10.1182/blood-2002-07-2314

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