Article
[Association of the extra-gonadal manifestations with different pathogenic gene mutations in male patients with congenital hypogonadotropic hypogonadism].
Zhonghua yi xue za zhi - 10 Nov 2015
Mao Jiangfeng, Chen Rongrong, Wu Xueyan, Liu Zhaoxiang, Zheng Junjie, Wang Xi, Nie Min, Duan Jing, Zhang Hongbing
Abstract excerpt
OBJECTIVE: To explore the relationships between pathogenic gene mutations and extra-gonadal manifestations in male patients with congenital hypogonadotropic hypogonadism (CHH). METHODS: A total of 15 genes were screened in 259 CHH patients by massively parallel DNA sequencing. The identified pathogenic mutations were confirmed by Sanger polymerase chain reaction (PCR). The extra-gonadal features in all patients...
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