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Article

Gene-environment interaction in functional hypothalamic amenorrhea.

Frontiers in endocrinology - 1 Jan 2024

Barbagallo Federica, Bosoni David, Perone Valeria, Cucinella Laura, Dealberti Davide, Cannarella Rossella, Calogero Aldo E, Nappi Rossella E

Abstract excerpt

Functional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea and chronic anovulation in adolescent girls and young women, diagnosed after excluding other organic causes. It is commonly associated with calorie restriction, excessive physical exercise, and psychosocial stress. These stressors alter the pulsatile secretion of gonadotropin-releasing hormone, leading to a chronic condition of...

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Identifiers

PMID: 39268244
DOI: 10.3389/fendo.2024.1423898
PMCID: PMC11390525

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