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Article

Hallmarks of Molecular Action of Microtubule Stabilizing Agents

19 Jan 2011

Abstract excerpt

Microtubule stabilizing agents (MSAs) comprise a class of drugs that bind to microtubule (MT) polymers and stabilize them against disassembly. Several of these agents are currently in clinical use as anticancer drugs, whereas others are in various stages of development. Nonetheless, there is insufficient knowledge about the molecular modes of their action. Recent studies from our laboratory utilizing...

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PMID: 21245138
DOI: 10.1074/jbc.m110.162214

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