Article
Up-regulation of MUC18 in airway epithelial cells by IL-13: implications in bacterial adherence.
American journal of respiratory cell and molecular biology - 1 May 2011
Simon Glenn C, Martin Richard J, Smith Sean, Thaikoottathil Jyoti, Bowler Russell P, Barenkamp Stephen J, Chu Hong Wei
Abstract excerpt
Airway bacterial infections are a major problem in lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Increased Th2 cytokines, such as IL-13, are observed in lung diseases and may contribute to bacterial infections. How Th2 cytokines affect bacterial infection remains unknown. MUC18, an adhesion molecule shown to be involved in the pathogenesis of malignant...
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