Article
Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases.
BMC systems biology - 12 Jan 2011
Ahmed Shiek S S J, Ahameethunisa Abdul R, Santosh Winkins, Chakravarthy Srinivasa, Kumar Suresh
Abstract excerpt
BACKGROUND: Systems biological approach of molecular connectivity map has reached to a great interest to understand the gene functional similarities between the diseases. In this study, we developed a computational framework to build molecular connectivity maps by integrating mutated and differentially expressed genes of neurological and psychiatric diseases to determine its relationship with aging. RESULTS: The...
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