Article
The heads of the measles virus attachment protein move to transmit the fusion-triggering signal.
Nature structural & molecular biology - 1 Feb 2011
Navaratnarajah Chanakha K, Oezguen Numan, Rupp Levi, Kay Leah, Leonard Vincent H J, Braun Werner, Cattaneo Roberto
Abstract excerpt
The measles virus entry system, consisting of attachment (hemagglutinin, H) and fusion proteins, operates by means of a variety of natural and targeted receptors; however, the mechanism that triggers fusion of the viral envelope with the plasma membrane is not understood. Here, we tested a model proposing that the two heads of an H dimer, which are covalently linked at their base, after binding two receptor...
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