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Article

Epigenetic regulation of the calcitonin gene–related peptide gene in trigeminal glia

7 Jan 2011

Abstract excerpt

BACKGROUND: The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine. CGRP gene expression involves an enhancer that is active in neurons, yet inactive in glia. In this report, we analyze epigenetic modifications that allow enhancer activation in glia. METHODS: DNA methylation and histone acetylation states were measured in rat and human- model cell lines and primary cultures of rat...

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PMID: 21216873
DOI: 10.1177/0333102410391487

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