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Article

Methylation of Migraine-Related Genes in Different Tissues of the Rat

7 Mar 2014

Abstract excerpt

17ß-Estradiol, an epigenetic modulator, is involved in the increased prevalence of migraine in women. Together with the prophylactic efficacy of valproate, which influences DNA methylation and histone modification, this points to the involvement of epigenetic mechanisms. Epigenetic studies are often performed on leukocytes, but it is unclear to what extent methylation is similar in other tissues. Therefore, we...

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PMID: 24609082
DOI: 10.1371/journal.pone.0087616

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